Evaluation of the Anti-Inflammatory Properties of Mastic Oil Extracted from Pistacia lentiscus var. chia

Mastic oil (MO) is extracted from the resin of bark Pistacia lentiscus var. chia, a tree abundantly grown in Greek island Chios. Various biological activities, such as antimicrobial, anticancer and antioxidant, have been associated with dietary intake MO. However, little known about MO’s potential anti-inflammatory effects, while some its main chemical constituents were reported to exert significant activity. This study aims assay bioactivity MO on vitro vivo experimental inflammation models, particular LPS-stimulated RAW264.7 macrophages, murine primary peritoneal macrophages model zymosan-induced peritonitis BALB/c mice. The per os administration inhibited recruitment into cavity zymosan-treated mice, but did not affect neutrophil mobilisation or levels IL-6 TNF-α fluid. Similarly, secretion was affected by MO, phosphoproteins that activate differentially regulated. Finally, individual reduced nitric oxide (NO), prostaglandin E2 supernatants cells their phagocytosis rate. Our data imply may promote an transition due combined bioactivities constituents. Thus, mixture various compounds, seems multiple molecular mechanisms are involved development inflammation. Therefore, more research, focusing employing pre-clinical models different mechanisms, required for detailed investigation oil’s